Endocrine Abstracts

Introduction: The ongoing, international, open, longitudinal, non-interventional study, PATRO Adults, aims to determine the long-term safety and efficacy of Omnitrope® (Sandoz), a recombinant human growth hormone (rhGH). Safety data from an interim analysis are presented here.Methods: Eligible patients are male or female adults who are receiving treatment with Omnitrope® and who have provided informed consent. Patients tre...

Introduction: Long-term survivors of childhood-onset brain tumours have increased risk of premature vascular disease by mechanisms that remain unclear. We hypothesised that a thrombotic fibrin network profile is one mechanism for the increased vascular risk in this population.Methods: We undertook a cross-sectional study in 33 patients with previous history of brain tumours and 33 age and sex-matched healthy controls. We performed clot structure analysis...

Background: Diagnosing secondary hypothyroidism can be challenging, particularly for patients with low-normal free T4 (fT4). Thyroid hormone replacement (THR) in these cases is guided by the normal population fT4 range. The aim of this study was to compare thyroid function tests in thyroid cancer patients on THR and patients with pituitary diseases with or without central hypothyroidism.Methods: We retrospectively collect...

Introduction: Prednisolone is the standard treatment for most inflammatory conditions. However, it is also used in hormone replacement therapy in adrenal insufficiency (AI) for historical reasons or due to its longer half-life and once-daily application. Recent data indicate that daily prednisolone could be associated with lower bone mineral density than daily hydrocortisone in patients with AI. However, data on risk factors for cardiovascular disease in patients with AI treat...

Introduction: PATRO adults is an international, longitudinal, non-interventional study of the long-term safety and efficacy of recombinant human growth hormone (rhGH; Omnitrope®, Sandoz). The study will provide additional data on the long-term safety of rhGH in adult patients with severe GH deficiency (GHD). Here, we present safety data from an interim analysis.Methods: Eligible patients are adults who are receiving treatment with Omnitro...

Introduction: Improved survival following treatment for paediatric medulloblastomas has resulted in increased incidence of late effects, particularly endocrine sequelae. The complete picture of late effects, however, has been limited by short duration of follow up.Aims 1: To establish the evolution of endocrine sequelae in patients treated for medulloblastomaAim 2: To compare the prevalence of endocrine dysfunction among three majo...

Background: Antithyroid drugs (ATDs) are preferred as a first-line treatment for Graves’ disease (GD). However, around 50–60% of patients relapse following treatment withdrawal. Radioactive iodine (RAI) or thyroidectomy is recommended for these patients, however, repeat ATD therapy is a further option, dependent upon patient choice. The long-term efficacy of ATD in relapsed GD has not been robustly established.Methods: We conducted a retrospect...

Background: Current therapeutic options for Graves’ disease (GD) include antithyroid drugs (ATD), radioactive iodine (RAI) or thyroidectomy. ATD treatment is widely used but the relatively high recurrence rate (~50%) after ATD discontinuation is a major concern. Identification of risk factors predicting relapse in GD patients after stopping ATD is decisive to guide initial treatment choices.Methods: We conducted a retrospective study to determine th...

Introduction: Childhood-onset cancer survivors demonstrate increased mortality rates due to cardiovascular and cerebrovascular events. Studies suggest that leukaemia and brain tumour survivors have a relative risk of 6.4 and 29.0 respectively for stroke. Adverse lipid profile, body composition, insulin resistance and hypertension have been implicated to the increased cardiovascular risk in these patients, however little is known about procoagulant factors and markers of vascul...

Introduction: Patients with acromegaly are frequently left with long-term adverse sequelae. Cross-sectional evaluation of health-related quality of life (HR-QoL) using both generic and specific questionnaires (AcroQoL) has confirmed HR-QoL to be severely impaired in acromegaly. However, long-term HR-QoL outcomes following disease control have been less well-described.Methods: The disease specific questionnaire AcroQoL and three validated generic question...